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TheNNT Rating System

The Green Rating
Therapies rated green are the best you can get

The Yellow Rating
Therapies rated yellow require more studies OR therapies with equal efficacy.

The Red Rating
Red suggest that benefits and harms may be equal or equivocal.

The Black Rating
Therapies rated black have very clear harms without any benefit.

Highlighted Reviews

01/29/2026

Noninvasive Respiratory Support for Pediatric Acute Hypoxemic Respiratory Failure

Continuous positive airway pressure (CPAP) reduced risk of invasive mechanical ventilation (IMV) compared to standard oxygen therapy (SOT), while both CPAP and high-flow nasal cannula (HFNC) reduced treatment failure compared to SOT

10/07/2025

Balanced Crystalloids for Pediatric Sepsis and Septic Shock

Balanced crystalloids reduced the risk of renal replacement therapy requirement when compared to normal saline

09/23/2025

Effect of Vitamin D Supplementation on Prevention of Acute Respiratory Infections

Vitamin D supplementation does not reduce the risk of acute respiratory infections (ARI)

Recent Reviews

08/28/2025

Fidaxomicin vs Vancomycin for Clostridioides difficile Infection

Fidaxomicin treatment resulted in a higher chance of sustained clinical resolution

08/26/2025

Safety of Treating Low-Risk Patients with Acute Pulmonary Embolism at Home

The incidence of mortality and/or adverse events in low-risk patients with PE (selected by a validated risk stratification tool) is very low

08/19/2025

Early versus Delayed Colonoscopy for Acute Lower Gastrointestinal Bleeding

Early colonoscopy within 24 h of presentation does not improve clinical outcomes such as further bleeding or mortality in patients hospitalized with acute LGIB

08/12/2025

Efficacy of Tirzepatide, Retatrutide, and Semaglutide for Weight Loss in Obese Individuals Without Diabetes

Glucagon-like peptide-1 receptor agonists and co-agonists are effective for weight loss in obese patients without diabetes who can tolerate the drug's adverse events

05/29/2025

Corticosteroids for Community-Acquired Bacterial Pneumonia

Corticosteroids reduced mortality (only for severe CAP), reduced need for invasive mechanical ventilation (intubation) and ICU admission as well as length of hospital and ICU stay

05/27/2025

Endovascular Therapy for Acute Vertebrobasilar Occlusion Stroke

Improved chance of favorable functional outcome (mRS 0–3) and functional independence (mRS 0–2); lower risk of death at 90 days; higher risk of symptomatic intracranial hemorrhage at 24–72 h compared to standard medical treatment

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