11/12/2024
Ketamine versus Etomidate for Induction of Intubation in Critically Ill Patients
Neither agent is demonstrably better or worse, and more data are needed
TheNNT Rating System
The Green Rating
Therapies rated green are the best you can get
Therapies rated green are the best you can get
The Yellow Rating
Therapies rated yellow require more studies OR therapies with equal efficacy.
Therapies rated yellow require more studies OR therapies with equal efficacy.
The Red Rating
Red suggest that benefits and harms may be equal or equivocal.
Red suggest that benefits and harms may be equal or equivocal.
The Black Rating
Therapies rated black have very clear harms without any benefit.
Therapies rated black have very clear harms without any benefit.
Highlighted Reviews
10/24/2024
Metformin for Type 2 Diabetes Mellitus
It is uncertain whether metformin reduces deaths, cardiovascular events, peripheral vascular events, or amputations
04/26/2024
Fluid Volumes in Adults with Sepsis
Less versus more intravenous fluid did not affect mortality in adults with sepsis
Recent Reviews
04/23/2024
Paxlovid for Nonhospitalized Patients with COVID-19
The effectiveness of nirmatrelvir/ritonavir (Paxlovid) in reducing mortality or hospitalization in mild to moderate COVID-19 is uncertain
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04/23/2024
SGLT-2 Inhibitors and GLP-1 Receptor Agonists for Type 2 Diabetes
Adding SGLT-2 inhibitors and GLP-1 agonists to standard treatment reduces death, nonfatal heart attack, and severe kidney disease in Type 2 diabetes, but also increases adverse events
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08/17/2023
Therapeutic Hypothermia Following Cardiac Arrest
Hypothermia following cardiac arrest does not improve the chance of survival or favorable neurologic outcome
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08/15/2023
Early vs. Delayed Coronary Angiography after out-of-Hospital Cardiac Arrest without ST-Segment Elevation
Early angiography in patients with OHCA without ST-elevation does not improve survival or chance of good neurological outcome
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08/10/2023
Direct Oral Anticoagulants vs. Conventional Anticoagulants for Pulmonary Embolism
No difference in death, recurrent VTE, or major bleeding when compared to conventional anticoagulation
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07/18/2023
Direct Oral Anticoagulants vs. Conventional Anticoagulants for Deep Vein Thrombosis
Direct oral anticoagulants have similar efficacy in the treatment of DVT compared to conventional anticoagulation but lower risk of major bleeding
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