05/14/2026
Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy
Alpha-lipoic acid shows little to no benefit over placebo for improving symptoms or impairment
Quick summaries of evidence-based medicine
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Highlighted Reviews
04/30/2026
Testosterone Replacement in Men With Sexual Dysfunction in the Absence of Hypogonadism
Testosterone replacement therapy shows no clear benefit over placebo
04/23/2026
Sustained-Release Naltrexone for Opioid Dependence
Sustained-release naltrexone reduces illicit opioid use compared to standard care but shows slightly worse outcomes than opioid agonists
Recent Reviews
04/09/2026
Gonadotropins for Infertility in Polycystic Ovary Syndrome
Gonadotropins increased live birth and clinical pregnancy rates
Read More about Gonadotropins for Infertility in Polycystic Ovary Syndrome04/07/2026
Surgical vs. Nonsurgical Treatments for Carpal Tunnel Syndrome
Surgery resulted in higher clinical improvement at long-term follow-up compared with splinting alone
Read More about Surgical vs. Nonsurgical Treatments for Carpal Tunnel Syndrome03/31/2026
Higher Versus Lower Mean Arterial Blood Pressure Targets in Vasodilatory Shock
Higher MAP targets are likely associated with increased 28-day all-cause mortality, less RRT-free days, and increased risk of arrhythmia
Read More about Higher Versus Lower Mean Arterial Blood Pressure Targets in Vasodilatory Shock02/17/2026
Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-of-Hospital Cardiac Arrest
Extracorporeal cardiopulmonary resuscitation did not improve favorable neurological status at the shortest follow-up and at 6 months or reduce in-hospital mortality when compared to conventional ACLS
Read More about Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-of-Hospital Cardiac Arrest02/12/2026
Intravenous Thrombolysis for Minor Acute Ischemic Stroke
Intravenous thrombolysis lowered functional independence and increased deaths at 90 days
Read More about Intravenous Thrombolysis for Minor Acute Ischemic Stroke01/29/2026
Noninvasive Respiratory Support for Pediatric Acute Hypoxemic Respiratory Failure
Continuous positive airway pressure (CPAP) reduced risk of invasive mechanical ventilation (IMV) compared to standard oxygen therapy (SOT), while both CPAP and high-flow nasal cannula (HFNC) reduced treatment failure compared to SOT
Read More about Noninvasive Respiratory Support for Pediatric Acute Hypoxemic Respiratory Failure